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Rainer Pages Pages Osteoarthritis: State of the Art Schumacher, H. Show next xx. Read this book on SpringerLink. Recommended for you. PAGE 1. But there's a lot you can do to feel better today.

There's a chance that, at some point in your life, you'll develop osteoarthritis OA. Not great odds, considering how much this joint condition can hamper your activity. The pain and limited mobility in OA occur as the cartilage that cushions the space between bones wears away with age and overuse.

Left bare of their padding, bones rub painfully against each other—particularly in the hands, spine, knees, and hips.

Bone Marrow Stem Cell Treatment (BMAC) for Knee Osteoarthritis - Mayo Clinic

For years, treatments have focused on relieving OA symptoms—nonsteroidal anti-inflammatory drugs NSAIDs and acetaminophen to control pain, steroid injections to bring down inflammation, and viscosupplements to replace the joint's natural lubricant. Today, the treatment outlook is changing.

5.1. Introduction

But we're beginning to realize that there are important changes happening in the bone underneath the cartilage, and in the joint lining itself—the synovium. As we begin to understand osteoarthritis as a disease of the entire joint, new treatment targets will emerge. One of the treatments in development isn't new at all. It's an osteoporosis drug called strontium ranelate, which has been used to treat bone loss in Europe; it's now finding a new purpose for knee OA.

Press Release: Ozone Gas Injections May Help Knee Osteoarthritis

How this drug works in OA is not clear, but it might protect bone under the cartilage," Dr. Aliprantis says. At the American College of Rheumatology annual meeting in November , researchers presented the results of a three-year study testing strontium ranelate. People with mild-to-moderate OA who took this drug had less narrowing of the joint, indicating a slowing of disease progression. Although the difference in joint narrowing wasn't huge, it was "encouraging," Dr. Other medications that target changes to the bone under the cartilage may also prove useful.

Stem cells, which are able to transform into many different types of cells, also show potential for treating OA. The hope is that injecting stem cells into damaged joints might help regenerate healthy tissue.

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Shoulder Osteoarthritis: Diagnosis and Management

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